From Raleigh:
I-40 to Wilmington. I-40 becomes College Rd. Continue on College Road past UNC-Wilmington which will be on the left, and St. Matthews, which will be on the right in front of the college. Go through several stop lights. The first large intersection will be the intersection of College and Oleander, which is also US 74/76. Continue to go straight towards Carolina Beach. At the second light past this intersection there will be a shopping center with a Harris Teeter and Eckerds on the right. Continue to go straight on College Rd. Messiah will be on the right past the Harris Teeter shopping center approximately 1/2 to 1 mile down.

From Charlotte:
US 74/75 to Wilmington. Cross the bridge at the Cape Fear and continue on Hwy 74/76. In about 1-2 miles, at a light, the road will allow you to bear right or go straight....bear right, continuing on Hwy 74/76. This now becomes Oleander. Continue on Oleander past the Independence Mall until you get to College Rd. Turn Right onto College Rd and follow the same directions as above.